Nature Communications (Mar 2023)
Longitudinal single-cell profiling of chemotherapy response in acute myeloid leukemia
- Matteo Maria Naldini,
- Gabriele Casirati,
- Matteo Barcella,
- Paola Maria Vittoria Rancoita,
- Andrea Cosentino,
- Carolina Caserta,
- Francesca Pavesi,
- Erika Zonari,
- Giacomo Desantis,
- Diego Gilioli,
- Matteo Giovanni Carrabba,
- Luca Vago,
- Massimo Bernardi,
- Raffaella Di Micco,
- Clelia Di Serio,
- Ivan Merelli,
- Monica Volpin,
- Eugenio Montini,
- Fabio Ciceri,
- Bernhard Gentner
Affiliations
- Matteo Maria Naldini
- San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute
- Gabriele Casirati
- Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Hospital
- Matteo Barcella
- San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute
- Paola Maria Vittoria Rancoita
- University Center for Statistics in the Biomedical Sciences (CUSSB), Vita-Salute San Raffaele University
- Andrea Cosentino
- San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute
- Carolina Caserta
- San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute
- Francesca Pavesi
- Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Hospital
- Erika Zonari
- San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute
- Giacomo Desantis
- San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute
- Diego Gilioli
- San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute
- Matteo Giovanni Carrabba
- Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Hospital
- Luca Vago
- Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Hospital
- Massimo Bernardi
- Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Hospital
- Raffaella Di Micco
- San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute
- Clelia Di Serio
- University Center for Statistics in the Biomedical Sciences (CUSSB), Vita-Salute San Raffaele University
- Ivan Merelli
- National Research Council, Institute for Biomedical Technologies
- Monica Volpin
- San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute
- Eugenio Montini
- San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute
- Fabio Ciceri
- Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Hospital
- Bernhard Gentner
- San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute
- DOI
- https://doi.org/10.1038/s41467-023-36969-0
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 20
Abstract
Relapse within acute myeloid leukaemia may be driven by the presence of leukaemia stem cells. Here, the authors use single cell RNA-seq seq to characterise leukemia stem cells, and show miR-126 as a potential marker of resistance.
