Fabry-Perot Interferometer Based on a Fiber-Tip Fixed-Supported Bridge for Fast Glucose Concentration Measurement
Shuo Tang,
Mengqiang Zou,
Cong Zhao,
Yihang Jiang,
Ribao Chen,
Zhourui Xu,
Chengbin Yang,
Xiaomei Wang,
Biqin Dong,
Yiping Wang,
Changrui Liao,
Gaixia Xu
Affiliations
Shuo Tang
Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering Health Science Center, Shenzhen University, Shenzhen 518055, China
Mengqiang Zou
Shenzhen Key Laboratory of Photonic Devices and Sensing Systems for Internet of Things, Guangdong and Hong Kong Joint Research Centre for Optical Fiber Sensors, Shenzhen University, Shenzhen 518060, China
Cong Zhao
Shenzhen Key Laboratory of Photonic Devices and Sensing Systems for Internet of Things, Guangdong and Hong Kong Joint Research Centre for Optical Fiber Sensors, Shenzhen University, Shenzhen 518060, China
Yihang Jiang
Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering Health Science Center, Shenzhen University, Shenzhen 518055, China
Ribao Chen
Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering Health Science Center, Shenzhen University, Shenzhen 518055, China
Zhourui Xu
Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering Health Science Center, Shenzhen University, Shenzhen 518055, China
Chengbin Yang
Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering Health Science Center, Shenzhen University, Shenzhen 518055, China
Xiaomei Wang
Base for International Science and Technology Cooperation: Carson Cancer Stem Cell Vaccines R&D Center, Shenzhen Key Laboratory of Synthetic Biology, Department of Physiology, School of Basic Medical Sciences Shenzhen University, Shenzhen 518055, China
Biqin Dong
Department of Civil Engineering, Guangdong Province Key Laboratory of Durability for Marine Civil Engineering, The Key Laboratory on Durability of Civil Engineering in Shenzhen, Shenzhen University, Shenzhen 518060, China
Yiping Wang
Shenzhen Key Laboratory of Photonic Devices and Sensing Systems for Internet of Things, Guangdong and Hong Kong Joint Research Centre for Optical Fiber Sensors, Shenzhen University, Shenzhen 518060, China
Changrui Liao
Shenzhen Key Laboratory of Photonic Devices and Sensing Systems for Internet of Things, Guangdong and Hong Kong Joint Research Centre for Optical Fiber Sensors, Shenzhen University, Shenzhen 518060, China
Gaixia Xu
Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering Health Science Center, Shenzhen University, Shenzhen 518055, China
Blood glucose concentration is important for metabolic homeostasis in humans and animals. Many diabetic patients need to detect blood glucose daily which burdens community hospitals and family healthcare. Optical fiber sensors are widely used in biomedical detection because of their compact structure, fast response, high sensitivity, low cost, and ease of operation. In this work, we constructed a Fabry-Perot (FP) cavity biosensor for the fast detection of glucose concentration in serum. The femtosecond laser micromachining was applied to fabricate the FP cavity by printing the fiber-tip fixed-supported bridge at the end face of the optical fiber. An additional hemisphere was printed at the center of the outer surface of the bridge to avoid multi-beam interference. The results demonstrated that the proposed biosensor had high refractive index (RI) detection sensitivity, roughly 1039 nm/RIU at a wavelength of 1590 nm, and the detection sensitivity for glucose was around 0.185 nm/ (mg/mL) at a wavelength of 1590 nm. Due to its high sensitivity, compact structure, and fast response, the FP cavity biosensor has great potential to be applied in family healthcare for glucose concentration detection of diabetic patients.
