Nature Communications (Oct 2021)
Rhesus macaques self-curing from a schistosome infection can display complete immunity to challenge
- Murilo Sena Amaral,
- Daisy Woellner Santos,
- Adriana S. A. Pereira,
- Ana Carolina Tahira,
- João V. M. Malvezzi,
- Patrícia Aoki Miyasato,
- Rafaela de Paula Freitas,
- Jorge Kalil,
- Elisa M. Tjon Kon Fat,
- Claudia J. de Dood,
- Paul L. A. M. Corstjens,
- Govert J. van Dam,
- Eliana Nakano,
- Simone de Oliveira Castro,
- Vânia Gomes de Moura Mattaraia,
- Ronaldo de Carvalho Augusto,
- Christoph Grunau,
- R. Alan Wilson,
- Sergio Verjovski-Almeida
Affiliations
- Murilo Sena Amaral
- Laboratório de Parasitologia, Instituto Butantan
- Daisy Woellner Santos
- Laboratório de Parasitologia, Instituto Butantan
- Adriana S. A. Pereira
- Laboratório de Parasitologia, Instituto Butantan
- Ana Carolina Tahira
- Laboratório de Parasitologia, Instituto Butantan
- João V. M. Malvezzi
- Laboratório de Parasitologia, Instituto Butantan
- Patrícia Aoki Miyasato
- Laboratório de Parasitologia, Instituto Butantan
- Rafaela de Paula Freitas
- Laboratório de Parasitologia, Instituto Butantan
- Jorge Kalil
- Heart Institute, Faculty of Medicine, University of Sao Paulo (USP)
- Elisa M. Tjon Kon Fat
- Department of Cell and Chemical Biology, Leiden University Medical Center
- Claudia J. de Dood
- Department of Cell and Chemical Biology, Leiden University Medical Center
- Paul L. A. M. Corstjens
- Department of Cell and Chemical Biology, Leiden University Medical Center
- Govert J. van Dam
- Department of Parasitology, Leiden University Medical Center
- Eliana Nakano
- Laboratório de Parasitologia, Instituto Butantan
- Simone de Oliveira Castro
- Instituto Butantan, Biotério Central
- Vânia Gomes de Moura Mattaraia
- Instituto Butantan, Biotério Central
- Ronaldo de Carvalho Augusto
- LBMC, Laboratoire de Biologie et Modélisation de la Cellule Univ Lyon, ENS de Lyon, Université Claude Bernard Lyon 1, CNRS, UMR 5239, INSERM
- Christoph Grunau
- IHPE, Univ. Perpignan Via Domitia, CNRS, IFREMER, Univ Montpellier
- R. Alan Wilson
- York Biomedical Research Institute, Department of Biology, University of York, Heslington
- Sergio Verjovski-Almeida
- Laboratório de Parasitologia, Instituto Butantan
- DOI
- https://doi.org/10.1038/s41467-021-26497-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
To date there is only one single drug with modest efficacy and no vaccine available to protect from schistosomiasis. Here, Amaral et al. characterize the self-cure process of rhesus macaques following primary infection and secondary challenge with Schistosoma mansoni to inform future vaccine development studies.
