Nature Communications (Jun 2021)
Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry
- Amit Kulkarni,
- Tiago Ferreira,
- Clemens Bretscher,
- Annabel Grewenig,
- Nazim El-Andaloussi,
- Serena Bonifati,
- Tiina Marttila,
- Valérie Palissot,
- Jubayer A. Hossain,
- Francisco Azuaje,
- Hrvoje Miletic,
- Lars A. R. Ystaas,
- Anna Golebiewska,
- Simone P. Niclou,
- Ralf Roeth,
- Beate Niesler,
- Amélie Weiss,
- Laurent Brino,
- Antonio Marchini
Affiliations
- Amit Kulkarni
- Laboratory of Oncolytic Virus Immuno-Therapeutics, German Cancer Research Center
- Tiago Ferreira
- Laboratory of Oncolytic Virus Immuno-Therapeutics, German Cancer Research Center
- Clemens Bretscher
- Laboratory of Oncolytic Virus Immuno-Therapeutics, German Cancer Research Center
- Annabel Grewenig
- Laboratory of Oncolytic Virus Immuno-Therapeutics, German Cancer Research Center
- Nazim El-Andaloussi
- Laboratory of Oncolytic Virus Immuno-Therapeutics, German Cancer Research Center
- Serena Bonifati
- Laboratory of Oncolytic Virus Immuno-Therapeutics, German Cancer Research Center
- Tiina Marttila
- Laboratory of Oncolytic Virus Immuno-Therapeutics, German Cancer Research Center
- Valérie Palissot
- Laboratory of Oncolytic Virus Immuno-Therapeutics, Luxembourg Institute of Health
- Jubayer A. Hossain
- Laboratory of Oncolytic Virus Immuno-Therapeutics, Luxembourg Institute of Health
- Francisco Azuaje
- Quantitative Biology Unit, Luxembourg Institute of Health
- Hrvoje Miletic
- Department of Biomedicine, University of Bergen
- Lars A. R. Ystaas
- Department of Biomedicine, University of Bergen
- Anna Golebiewska
- NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health
- Simone P. Niclou
- NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health
- Ralf Roeth
- nCounter Core Facility, Institute of Human Genetics, University of Heidelberg
- Beate Niesler
- nCounter Core Facility, Institute of Human Genetics, University of Heidelberg
- Amélie Weiss
- Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)
- Laurent Brino
- Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)
- Antonio Marchini
- Laboratory of Oncolytic Virus Immuno-Therapeutics, German Cancer Research Center
- DOI
- https://doi.org/10.1038/s41467-021-24034-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
Rat H-1 parvovirus (H-1PV) is in clinical development for oncolytic therapy. Here, Kulkarni et al. identify LAMC1 as a modulator of H-1PV cell attachment and entry and find that LAMC1 levels and H-1PV oncolytic activity correlate in 59 tested cancer cell lines.
