Frontiers in Aging Neuroscience (May 2023)
Mendelian randomization analyses of smoking and Alzheimer’s disease in Chinese and Japanese populations
- Yuan Zhu,
- Ying Guan,
- Xuewen Xiao,
- Bin Jiao,
- Bin Jiao,
- Bin Jiao,
- Xinxin Liao,
- Xinxin Liao,
- Xinxin Liao,
- Hui Zhou,
- Xixi Liu,
- Feiyan Qi,
- Qiyuan Peng,
- Lu Zhou,
- Tianyan Xu,
- Qijie Yang,
- Sizhe Zhang,
- Meng Li,
- Zhouhai Zhu,
- Sheming Lu,
- Jinchen Li,
- Beisha Tang,
- Beisha Tang,
- Lu Shen,
- Lu Shen,
- Lu Shen,
- Jianhua Yao,
- Yafang Zhou,
- Yafang Zhou,
- Yafang Zhou
Affiliations
- Yuan Zhu
- Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
- Ying Guan
- Joint Institute of Tobacco and Health, Kunming, Yunnan, China
- Xuewen Xiao
- Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
- Bin Jiao
- Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
- Bin Jiao
- Engineering Research Center of Hunan Province in Cognitive Impairment Disorders, Central South University, Changsha, China
- Bin Jiao
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Xinxin Liao
- Engineering Research Center of Hunan Province in Cognitive Impairment Disorders, Central South University, Changsha, China
- Xinxin Liao
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Xinxin Liao
- Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, China
- Hui Zhou
- Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
- Xixi Liu
- Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
- Feiyan Qi
- Joint Institute of Tobacco and Health, Kunming, Yunnan, China
- Qiyuan Peng
- Joint Institute of Tobacco and Health, Kunming, Yunnan, China
- Lu Zhou
- Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
- Tianyan Xu
- Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
- Qijie Yang
- Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
- Sizhe Zhang
- Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
- Meng Li
- Joint Institute of Tobacco and Health, Kunming, Yunnan, China
- Zhouhai Zhu
- Joint Institute of Tobacco and Health, Kunming, Yunnan, China
- Sheming Lu
- Joint Institute of Tobacco and Health, Kunming, Yunnan, China
- Jinchen Li
- Bioinformatics Center & National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Beisha Tang
- Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
- Beisha Tang
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Lu Shen
- Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
- Lu Shen
- Engineering Research Center of Hunan Province in Cognitive Impairment Disorders, Central South University, Changsha, China
- Lu Shen
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Jianhua Yao
- Joint Institute of Tobacco and Health, Kunming, Yunnan, China
- Yafang Zhou
- Engineering Research Center of Hunan Province in Cognitive Impairment Disorders, Central South University, Changsha, China
- Yafang Zhou
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Yafang Zhou
- Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, China
- DOI
- https://doi.org/10.3389/fnagi.2023.1157051
- Journal volume & issue
-
Vol. 15
Abstract
BackgroundPrevious epidemiological studies have reported controversial results on the relationship between smoking and Alzheimer’s disease (AD). Therefore, we sought to assess the association using Mendelian randomization (MR) analysis.MethodsWe used single nucleotide polymorphisms (SNPs) associated with smoking quantity (cigarettes per day, CPD) from genome-wide association studies (GWAS) of Japanese population as instrumental variables, then we performed two-sample MR analysis to investigate the association between smoking and AD in a Chinese cohort (1,000 AD cases and 500 controls) and a Japanese cohort (3,962 AD cases and 4,074 controls), respectively.ResultsGenetically higher smoking quantity showed no statistical causal association with AD risk (the inverse variance weighted (IVW) estimate in the Chinese cohort: odds ratio (OR) = 0.510, 95% confidence interval (CI) = 0.149–1.744, p = 0.284; IVW estimate in the Japanese cohort: OR = 1.170, 95% confidence interval CI = 0.790–1.734, p = 0.434).ConclusionThis MR study, for the first time in Chinese and Japanese populations, found no significant association between smoking and AD.
Keywords
- Alzheimer’s disease
- smoking
- two-sample Mendelian randomization analysis
- causal association
- East Asian population
