Histone H4 lysine 16 acetylation controls central carbon metabolism and diet-induced obesity in mice

Cecilia Pessoa Rodrigues; Aindrila Chatterjee; Meike Wiese; Thomas Stehle; Witold Szymanski; Maria Shvedunova; Asifa Akhtar

doi:10.1038/s41467-021-26277-w

Nature Communications (Oct 2021)

Histone H4 lysine 16 acetylation controls central carbon metabolism and diet-induced obesity in mice

Cecilia Pessoa Rodrigues,
Aindrila Chatterjee,
Meike Wiese,
Thomas Stehle,
Witold Szymanski,
Maria Shvedunova,
Asifa Akhtar

Affiliations

Cecilia Pessoa Rodrigues: Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics
Aindrila Chatterjee: Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics
Meike Wiese: Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics
Thomas Stehle: Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics
Witold Szymanski: Proteomics Facility, Max Planck Institute of Immunobiology and Epigenetics
Maria Shvedunova: Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics
Asifa Akhtar: Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics

DOI: https://doi.org/10.1038/s41467-021-26277-w
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 21

Abstract

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Misregulation of chromatin has been linked to many conditions, including obesity, but the details remain unclear. Here the authors identify the H4 lysine 16 acetyltransferase MOF as a master regulator of glucose metabolism that is required for normal glucose uptake and fat storage.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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