BIOMARKERS OF IMMUNE TOLERANCE IN LIVER TRANSPLANTATION

Abstract

This review of literature is dedicated to the analysis of the current studies of biomarkers, which could help predict immune tolerance development and identify the patients, who can safely minimize immunosuppression after liver transplantation. The review analyzed 46 sources of literature, more than half of those were published in the last fi ve years. Up to date advanced technologies are intensively developed, which help understand molecular mechanisms of normal, pathological and pharmacological processes involved in organ transplantations. However, there are no biomarkers yet validated for the identifi cation of immune tolerance development or individual prescription of immunosuppressants. Further data collection on patients along with the progress in bioinformatics could accelerate development of approaches for patient stratifi cation.

Keywords

• immune tolerance
• biomarkers
• liver transplantation
• immunosuppression