INHALED COLISTIN USE IN A NEUTROPENIC PATIENT.

Abstract

Abstract Fifty nine years old man who was diagnosed as mantle cell lymphoma relapsed after high dose chemotherapy with peripheral stem cell rescue. One course of R- Hyper CVAD regimen followed by high dose metotreaxate and cytrabine regimen was applied. Seven days after therapy he had neutropenic fever, sepsis and he followed in intensive care units (ICU) with ventilation support. Sputum culture revealed multi-drug resistant Pseudomonas aeruginosa. Intravenous colistin and meropenem was started .Because of seven days after his condition did’nt improve, inhaled and intravenous colistin combination with meropenem was used. Two weeks later this therapy, his pneumonia and septic situation were regression, he was clinically stable. Pseudomonas aeruginosa is a nosocomial pathogen which generally causes infections in ICUs or immunocompromised patients. Prolonged neutropenia and mechanical ventilation increase the risk of lower respiratory tract infections due to Pseudomonas spp. Colistin concentration is higher in sputum and lungs when it is used by inhalation and has more effective killing activity to the pathogens caused pneumonia. Aerolized colistin therapy concomitant with intravenous form may be an option for a successful treatment of infections due to these difficult to treat pathogens in these patients. Key Words: Pseudomonas Infections, Immunosuppression, Lymphoma, Mantle-Cell, Drug Resistance, Multiple, Bacterial

Keywords

• Pseudomonas Infections
• Immunosuppression
• Lymphoma
• Mantle-Cell
• Drug Resistance
• Multiple