Side Effects of the Immune System: Lessons from Tuberculosis-Related Immune Reconstitution Inflammatory Syndrome

D. Buonsenso; T. Pirronti; O. Genovese; L. Gargiullo; O. Ranno; P. Valentini

doi:10.1177/1721727X1201000101

European Journal of Inflammation (Jan 2012)

Side Effects of the Immune System: Lessons from Tuberculosis-Related Immune Reconstitution Inflammatory Syndrome

D. Buonsenso,
T. Pirronti,
O. Genovese,
L. Gargiullo,
O. Ranno,
P. Valentini

Affiliations

D. Buonsenso: Department of Pediatrics, A. Gemelli Hospital-Catholic University of the Sacred Heart, Rome, Italy
T. Pirronti: Department of Bioimaging and Radiological Sciences, A. Gemelli Hospital-Catholic University of the Sacred Heart, Rome, Italy
O. Genovese: Department of Anesthesiology and Intensive Care, A. Gemelli Hospital-Catholic University of the Sacred Heart, Rome, Italy
L. Gargiullo: Department of Pediatrics, A. Gemelli Hospital-Catholic University of the Sacred Heart, Rome, Italy
O. Ranno: Department of Pediatrics, A. Gemelli Hospital-Catholic University of the Sacred Heart, Rome, Italy
P. Valentini: Department of Pediatrics, A. Gemelli Hospital-Catholic University of the Sacred Heart, Rome, Italy

DOI: https://doi.org/10.1177/1721727X1201000101
Journal volume & issue: Vol. 10

Abstract

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Immune reconstitution inflammatory syndrome (IRIS) is a recently described syndrome among human immunodeficiency virus (HIV)-infected patients attributable to the recovery of the immune system during antiretroviral therapy. A growing number of researches on this syndrome have been conducted in recent years, but IRIS in children has not been widely studied. We report the case of a 4.5 month-old, tuberculosis (TB)-HIV co-infected girl who developed IRIS two months after beginning antiretroviral and anti-TB medications. We moreover review the immunopathogenesis of TB-HIV coinfection and IRIS, with particular regard to TB-related IRIS.

Published in European Journal of Inflammation

ISSN: 1721-727X (Print); 2058-7392 (Online)
Publisher: SAGE Publishing
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://journals.sagepub.com/home/eji

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