Viral coinfection promotes tuberculosis immunopathogenesis by type I IFN signaling-dependent impediment of Th1 cell pulmonary influx

Tae Gun Kang; Kee Woong Kwon; Kyungsoo Kim; Insuk Lee; Myeong Joon Kim; Sang-Jun Ha; Sung Jae Shin

doi:10.1038/s41467-022-30914-3

Nature Communications (Jun 2022)

Viral coinfection promotes tuberculosis immunopathogenesis by type I IFN signaling-dependent impediment of Th1 cell pulmonary influx

Tae Gun Kang,
Kee Woong Kwon,
Kyungsoo Kim,
Insuk Lee,
Myeong Joon Kim,
Sang-Jun Ha,
Sung Jae Shin

Affiliations

Tae Gun Kang: Department of Biochemistry, College of Life Science & Biotechnology, Yonsei University
Kee Woong Kwon: Department of Microbiology, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine
Kyungsoo Kim: Department of Biochemistry, College of Life Science & Biotechnology, Yonsei University
Insuk Lee: Department of Biotechnology, College of Life Science & Biotechnology, Yonsei University
Myeong Joon Kim: Department of Biochemistry, College of Life Science & Biotechnology, Yonsei University
Sang-Jun Ha: Department of Biochemistry, College of Life Science & Biotechnology, Yonsei University
Sung Jae Shin: Department of Microbiology, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine

DOI: https://doi.org/10.1038/s41467-022-30914-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 19

Abstract

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Viral coinfection alongside mycobacterium tuberculosis (Mtb) infection may lead to immune complications or interference with immune responses. Here the authors show that in mice infected with Mtb and LCMV virus the specific TH1 response to MTb is reduced through a type I IFN response to the infecting virus.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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