Nature Communications (Oct 2022)
A BDNF-TrkB autocrine loop enhances senescent cell viability
- Carlos Anerillas,
- Allison B. Herman,
- Rachel Munk,
- Amanda Garrido,
- Kwan-Wood Gabriel Lam,
- Matthew J. Payea,
- Martina Rossi,
- Dimitrios Tsitsipatis,
- Jennifer L. Martindale,
- Yulan Piao,
- Krystyna Mazan-Mamczarz,
- Jinshui Fan,
- Chang-Yi Cui,
- Supriyo De,
- Kotb Abdelmohsen,
- Rafael de Cabo,
- Myriam Gorospe
Affiliations
- Carlos Anerillas
- Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health
- Allison B. Herman
- Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health
- Rachel Munk
- Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health
- Amanda Garrido
- Translational Gerontology Branch, National Institute on Aging Intramural Research Program, National Institutes of Health
- Kwan-Wood Gabriel Lam
- Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health
- Matthew J. Payea
- Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health
- Martina Rossi
- Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health
- Dimitrios Tsitsipatis
- Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health
- Jennifer L. Martindale
- Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health
- Yulan Piao
- Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health
- Krystyna Mazan-Mamczarz
- Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health
- Jinshui Fan
- Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health
- Chang-Yi Cui
- Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health
- Supriyo De
- Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health
- Kotb Abdelmohsen
- Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health
- Rafael de Cabo
- Translational Gerontology Branch, National Institute on Aging Intramural Research Program, National Institutes of Health
- Myriam Gorospe
- Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-022-33709-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Selective elimination of senescent cells is an approach that has shown promise to ameliorate age-associated pathologies in preclinical models. Here the authors report that BDNF enhances senescent cell viability via TrkB in cultured cells, and that TrkB inhibition can reduce the accumulation of senescent cells in aged mouse organs.
