Relation of Red Cell Distribution Widht with Ascending Aortic Diameter in Bicuspid Aortic Valve Patients

Abstract

Objective: Red cell distribution widht (RDW) and neutrophil to lymphocyte ratio (NLR) plays a significant role in assessing the severity and progression of some cardiac conditions. Bicuspid aortic valve (BAV)-associated aortopathy is common and its progression for individual patients is difficult to predict. In this study, we aimed to investigate the association between serum levels of RDW, NLR and ascending aortic diameter (AAd) in BAV patients. Methods: A total of 182 consecutive patients with a BAV were recruited into this study. Complete blood counts were analyzed for RDW level and NLR. Patients were divided into two groups based on their AAd and patients with AAd of 3.9 and above were included in group 1, while those below 3.9 in group 2. Results: NLR was significantly higher in group 1 patients than those in group 2. RDW levels were similar. In univariate correlation analysis, a positive correlation was found between AAd and RDW and NLR in group 1 patients. In multivariate logistic regression analysis, RDW (odds ratio (OR): 1.78, 95% confidence interval (CI): 1.36–2.44, P = 0.01) remained as independent correlates of AAd in the patient population. Receiver operating characteristic (ROC) curve analysis reveled that a RDW measurement gt;13.0% predicted ascending aort dilatation (AAD) with a sensitivity of 58% and a specificity of 79%. Conclusion: RDW and NLR are positively correlated with AAd in BAV patients with AAD. These markers may point out the role of inflammation both in the pathogenesis and progression of AAD in these patients.

Keywords

• bicuspid aortic valve
• ascending aortic diameter
• red cell distribution widht
• bicuspid aortic valve
• ascending aortic diameter
• red cell distribution widht