Silver-Promoted Radical Cascade Aryldifluoromethylation/Cyclization of 2-Allyloxybenzaldehydes for the Synthesis of 3-Aryldifluoromethyl-Containing Chroman-4-one Derivatives
Qianqian Sun,
Hongxiao Li,
Xingyu Chen,
Jian Hao,
Hongmei Deng,
Haizhen Jiang
Affiliations
Qianqian Sun
Department of Chemistry, Shanghai University, Shanghai 200444, China
Hongxiao Li
Department of Chemistry, Shanghai University, Shanghai 200444, China
Xingyu Chen
Department of Chemistry, Shanghai University, Shanghai 200444, China
Jian Hao
Department of Chemistry, Shanghai University, Shanghai 200444, China
Hongmei Deng
Laboratory for Microstructures, Shanghai University, Shanghai 200444, China
Haizhen Jiang
Department of Chemistry, Shanghai University, Shanghai 200444, China
A convenient silver-promoted radical cascade aryldifluoromethylation/cyclization of 2-allyloxybenzaldehydes has been developed. Experimental studies disclosed that the addition of aryldifluoromethyl radicals in situ produced from easily accessible gem-difluoroarylacetic acids to unactivated double bonds in 2-allyloxybenzaldehyde was an effective route to access a series of 3-aryldifluoromethyl-containing chroman-4-one derivatives in moderate to good yields under mild reaction conditions.
