Malignant transformation of a dysembryoplastic neuroepithelial tumor presenting with intraventricular hemorrhage

Hirotaka Takita, MD; Taro Shimono, MD, PhD; Takehiro Uda, MD, PhD; Hayato Ikota, MD, PhD; Toshiyuki Kawashima, MD, PhD; Daisuke Horiuchi, MD; Eisaku Terayama, MD; Taro Tsukamoto, MD, PhD; Yukio Miki, MD, PhD

Radiology Case Reports (Mar 2022)

Malignant transformation of a dysembryoplastic neuroepithelial tumor presenting with intraventricular hemorrhage

Hirotaka Takita, MD,
Taro Shimono, MD, PhD,
Takehiro Uda, MD, PhD,
Hayato Ikota, MD, PhD,
Toshiyuki Kawashima, MD, PhD,
Daisuke Horiuchi, MD,
Eisaku Terayama, MD,
Taro Tsukamoto, MD, PhD,
Yukio Miki, MD, PhD

Affiliations

Hirotaka Takita, MD: Department of Diagnostic and Interventional Radiology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan; Corresponding author. H. Takita
Taro Shimono, MD, PhD: Department of Diagnostic and Interventional Radiology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan
Takehiro Uda, MD, PhD: Department of Neurosurgery, Graduate School of Medicine, Osaka City University, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan
Hayato Ikota, MD, PhD: Clinical Department of Pathology, Gunma University Hospital, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan
Toshiyuki Kawashima, MD, PhD: Department of Neurosurgery, Graduate School of Medicine, Osaka City University, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan
Daisuke Horiuchi, MD: Department of Diagnostic and Interventional Radiology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan
Eisaku Terayama, MD: Department of Diagnostic and Interventional Radiology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan
Taro Tsukamoto, MD, PhD: Department of Diagnostic and Interventional Radiology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan
Yukio Miki, MD, PhD: Department of Diagnostic and Interventional Radiology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan

Journal volume & issue: Vol. 17, no. 3
pp. 939 – 943

Abstract

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Dysembryoplastic neuroepithelial tumors (DNTs) are benign brain tumors classified as grade 1 in the 2021 World Health Organization (WHO) classification of central nervous system tumors. DNTs rarely undergo malignant transformation and cause symptomatic intracranial hemorrhage. We report a case of malignant transformation of DNT presenting with intraventricular hemorrhage and review the literature on malignant transformation of DNTs. An 18-year-old woman with a history of epilepsy presented with a sudden headache and vomiting. Radiological examination revealed a mass lesion in the left parietal lobe and intraventricular hemorrhage. The patient underwent an emergency craniotomy for brain tumor resection. The lesion was pathologically diagnosed as a malignant transformation of DNT. She had been followed up without tumor recurrence for 2 years after surgery.

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

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