9-Aminoquino[2',3':3,4]pyrrolo[2,1-b]quinazolin-11(13H)-one

Abstract

Chemoselective reduction of the corresponding 9-nitro precursor by catalytic transfer hydrogenation afforded the title compound, a new 9-amino derivative of the antitumor alkaloid Luotonin A, in good yield. The structure of the compound was established by means of 1D and 2D 1H-NMR and 13C-NMR spectroscopy as well as by EI-MS and high-resolution ESI-MS.

Keywords

• Luotonin A
• nitro group reduction
• catalytic transfer hydrogenation