Lack of Protection Against Ebola Virus from Chloroquine in Mice and Hamsters

Abstract

The antimalarial drug chloroquine has been suggested as a treatment for Ebola virus infection. Chloroquine inhibited virus replication in vitro, but only at cytotoxic concentrations. In mouse and hamster models, treatment did not improve survival. Chloroquine is not a promising treatment for Ebola. Efforts should be directed toward other drug classes.

Keywords

• Ebola virus infection
• antiviral drug
• animal model
• chloroquine
• treatment
• viruses