Inflammation and Aging of Hematopoietic Stem Cells in Their Niche

Daozheng Yang; Gerald de Haan

doi:10.3390/cells10081849

Cells (Jul 2021)

Inflammation and Aging of Hematopoietic Stem Cells in Their Niche

Daozheng Yang,
Gerald de Haan

Affiliations

Daozheng Yang: European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands
Gerald de Haan: European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands

DOI: https://doi.org/10.3390/cells10081849
Journal volume & issue: Vol. 10, no. 8
p. 1849

Abstract

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Hematopoietic stem cells (HSCs) sustain the lifelong production of all blood cell lineages. The functioning of aged HSCs is impaired, including a declined repopulation capacity and myeloid and platelet-restricted differentiation. Both cell-intrinsic and microenvironmental extrinsic factors contribute to HSC aging. Recent studies highlight the emerging role of inflammation in contributing to HSC aging. In this review, we summarize the recent finding of age-associated changes of HSCs and the bone marrow niche in which they lodge, and discuss how inflammation may drive HSC aging.

Published in Cells

ISSN: 2073-4409 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Cytology
Website: https://www.mdpi.com/journal/cells

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Abstract

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