Frontiers in Human Neuroscience (Nov 2020)
The Use of Tractography-Based Targeting in Deep Brain Stimulation for Psychiatric Indications
- Benjamin Davidson,
- Benjamin Davidson,
- Benjamin Davidson,
- Nir Lipsman,
- Nir Lipsman,
- Nir Lipsman,
- Ying Meng,
- Ying Meng,
- Ying Meng,
- Jennifer S. Rabin,
- Jennifer S. Rabin,
- Jennifer S. Rabin,
- Peter Giacobbe,
- Peter Giacobbe,
- Peter Giacobbe,
- Clement Hamani,
- Clement Hamani,
- Clement Hamani
Affiliations
- Benjamin Davidson
- Sunnybrook Research Institute, Toronto, ON, Canada
- Benjamin Davidson
- Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
- Benjamin Davidson
- Division of Neurosurgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
- Nir Lipsman
- Sunnybrook Research Institute, Toronto, ON, Canada
- Nir Lipsman
- Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
- Nir Lipsman
- Division of Neurosurgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
- Ying Meng
- Sunnybrook Research Institute, Toronto, ON, Canada
- Ying Meng
- Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
- Ying Meng
- Division of Neurosurgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
- Jennifer S. Rabin
- Sunnybrook Research Institute, Toronto, ON, Canada
- Jennifer S. Rabin
- Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
- Jennifer S. Rabin
- Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
- Peter Giacobbe
- Sunnybrook Research Institute, Toronto, ON, Canada
- Peter Giacobbe
- Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
- Peter Giacobbe
- Department of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
- Clement Hamani
- Sunnybrook Research Institute, Toronto, ON, Canada
- Clement Hamani
- Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
- Clement Hamani
- Division of Neurosurgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
- DOI
- https://doi.org/10.3389/fnhum.2020.588423
- Journal volume & issue
-
Vol. 14
Abstract
Deep Brain Stimulation (DBS) has been investigated as a treatment option for patients with refractory psychiatric illness. Over the past two decades, neuroimaging developments have helped to advance the field, particularly the use of diffusion tensor imaging (DTI) and tractographic reconstruction of white-matter pathways. In this article, we review translational considerations and how DTI and tractography have been used to improve targeting during DBS surgery for depression, obsessive compulsive disorder (OCD) and post-traumatic stress disorder (PTSD).
Keywords
- deep brain stimulation
- depression
- obsessive compulsive disorder
- post-traumatic stress disorder
- diffusion tensor imaging
- tractography
