Dyslipidemia Pattern Among Newly Diagnosed and Known Type 2 Diabetics: A Comparative Analysis from a Tertiary Care Hospital of Karachi, Pakistan

Abstract

Objective: To compare the pattern of dyslipidemia among newly diagnosed and known type 2 diabetic patients. Study design, settings and duration: This retrospective study was conducted at Baqai institute of Diabetology and Endocrinology and Baqai Medical University, (BMU), a tertiary care unit in Karachi, Pakistan from January 2005 to May 2016. Methodology: Subjects with type 2 diabetes were included and subjects with gestational diabetes and type 1 diabetes were excluded. Medical records were obtained through electronic database (Health Management System). Results: Out of 12256 subjects, 57.7% were male and 42.3% female. Mean age was 52.46±10.94. Mean body mass index (BMI) was 28.35±5.49, in newly diagnosed individuals BMI was 29±5.79 while 28.2±5.41 in individuals with known diabetes. Overall dyslipidemia was found in 10231 (83.5%) subjects. Among types of dyslipidemia, hypercholesterolemia, hypertriglyceridemia and low HDL was significantly associated with diabetes status and hypercholesterolemia, hypertriglyceridemia, dyslipidemia, high LDL and low HDL was significantly associated with obesity. Logistic regression revealed the significant correlates of dyslipidemia with female gender, age and obesity in newly diagnosed diabetics while female gender, age, obesity and hypertension in known diabetics. Conclusion: We conclude that majority of the diabetics either newly diagnosed or known both have disturbed lipid parameters. Specifically, the pattern in newly diagnosed cases is alarmingly high. Further larger scale community-based studies are required to ascertain the findings of this study.

Keywords

• Dyslipidemia
• diabetes
• hyperglycemia
• Pakistani population