A histological response to antiviral therapy for chronic hepatitis C in patients who failed to achieve a sustained virological response

Abstract

The paper presents the results of combination antiviral therapy (AVT) in 2 patients with chronic hepatitis C (CHC) unresponsive to AVT. Both patients are classified as difficult to treat (genotype 1b, a high viral load, overweight). 1.5 years after the termination of a course of AVT, histological examination of biopsy specimens revealed a histological response in one patient and significant histological worsening in the other. The specific features of the development of a histological response to AVT and possible reasons for its lack are discussed by the example of the described patients.

Keywords

• chronic hepatitis c
• antiviral therapy
• histological response
• sustained virological response
• hepatic fibrosis