Nature Communications (Aug 2022)

Integrated multi-omics reveals cellular and molecular interactions governing the invasive niche of basal cell carcinoma

  • Laura Yerly,
  • Christine Pich-Bavastro,
  • Jeremy Di Domizio,
  • Tania Wyss,
  • Stéphanie Tissot-Renaud,
  • Michael Cangkrama,
  • Michel Gilliet,
  • Sabine Werner,
  • François Kuonen

DOI
https://doi.org/10.1038/s41467-022-32670-w
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 16

Abstract

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The role of reciprocal tumour-stroma interactions in tumour invasion remains poorly characterised. Here, single-cell and spatial transcriptomics identifies the cell populations and their transcriptional reprogramming contributing to the spatial organization of the basal cell carcinoma invasive niche.