Lung Cancer: Targets and Therapy (Apr 2025)
Prevalence of EGFR Mutations in Vietnamese Patients with Resected Early Stage Non-Small Cell Lung Cancer: EARLY-EGFR Study
Abstract
Tu Van Dao,1,2,* Van Luong Dinh,3,4,* Thanh Vinh Doan,5 Tri Le Phuong6 1Cancer Research and Clinical Trials Center, Department of Optimal Therapy, Vietnam National Cancer Hospital, Hanoi, Vietnam; 2Oncology Department, Hanoi Medical University, Hanoi, Vietnam; 3Lung Transplant Center, National Lung Hospital, Hanoi, Vietnam; 4TB and Lung Diseases Department, Hanoi Medical University, Hanoi, Vietnam; 5Oncology Department, Pham Ngoc Thach Hospital, Ho Chi Minh City, Vietnam; 6Medical Affairs, AstraZeneca Vietnam, Ho Chi Minh City, Vietnam*These authors contributed equally to this workCorrespondence: Tu Van Dao, Cancer Research and Clinical Trials Center, Department of Optimal Therapy, Vietnam National Cancer Hospital, Hanoi, Vietnam, Email [email protected]: Comprehensive profiling of mutations in the EGFR gene is vital for selecting patients eligible for EGFR targeted therapies.Methods: We investigated the prevalence of EGFR mutations and treatment patterns in patients with early stage non-small cell lung cancer (NSCLC) in Vietnam as a part of EARLY-EGFR (Clinical Trial Identifier: NCT04742192), a global, real-world study. Consecutive patients with surgically resected stage IA-IIIB, non-squamous NSCLC were diagnosed from August 2021 to June 2022 and were prospectively enrolled from November 2021 to July 2022.Results: A total 200 patients (age: median [range], 60.0 [30.0– 80.0] years) were enrolled from 3 centers; 56.0% were males and 64.0% never smoked. The prevalence of EGFR mutations was 51.0% (102/200) including deletions in exon-19 (49.0%) and exon-21 L858R mutations (33.3%). Females (73.9%, 65/88), patients aged ≥ 60 years (52.5%, 53/101), nonsmokers (61.2%, 63/103) and those with stage I (55.8%, 67/120) had higher prevalence of EGFR mutations. Multivariate analysis (adjusted odds ratio [aOR]) showed EGFR mutations to be significantly associated (p < 0.05) with female gender (aOR = 5.90), age ≥ 60 years (aOR = 1.05), and stage III disease (vs stage I) (aOR = 0.30).Conclusion: These results underscore the need for EGFR testing early in management algorithm of NSCLC in Vietnam to identify patients eligible for targeted therapy in concordance with international guidelines.Keywords: epidermal growth factor receptor mutations, EGFRm, early-stage resectable non-small cell lung cancer, targeted therapies, Vietnam
