Pathogenetic mechanisms for the development of atrial fibrillation at various stages of reproductive aging in women

Abstract

Background. Study of connection between atrial fibrillation (AF) and reproductive aging has is important for prevention and treatment of arrhythmias. Many researchers consider it appropriate to study this issue for an adequate selection of therapy. The purpose of the research was to study the relationship of paroxysms of atrial fibrillation (AFP) in women with age-related changes in the reproductive system. Material and methods. 157 women with AFP examined and divided into three groups, depending on the stage of reproductive aging. The 1st group includes 48 persons with AFP, occurred in the reproductive period, in the 2nd group there are 57 patients with AFP occurred in the premenopausal period, and in the 3rd group – 52 persons with AFP occurred in menopausal period. Research methods included ECG, Holter’s ECG monitoring, electrophysiological examination of the heart, stress tests, ultrasound of the heart, endocrine criteria for aging of the reproductive system of women. Results. A close (p<0.05) relationship was established between a number and duration of AFP and hormonal predictors of aging in women. A regression model was designed to predict the course of AF paroxysms. It was revealed that the predictive value of the equation is 99.2 %. Conclusions. The conducted study indicates a close relationship between atrial fibrillation and age-related dysfunction of endocrine reproductive dysfunction in women.

Keywords

• atrial fibrillation
• reproductive health
• arrhythmia