Metagenome-Wide Analysis of Rural and Urban Surface Waters and Sediments in Bangladesh Identifies Human Waste as a Driver of Antibiotic Resistance
Ross Stuart McInnes,
Md Hassan uz-Zaman,
Imam Taskin Alam,
Siu Fung Stanley Ho,
Robert A. Moran,
John D. Clemens,
Md Sirajul Islam,
Willem van Schaik
Affiliations
Ross Stuart McInnes
Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom
Md Hassan uz-Zaman
The Laboratory of Food Safety and One Health, Laboratory Sciences and Services Division, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh
Imam Taskin Alam
The Laboratory of Food Safety and One Health, Laboratory Sciences and Services Division, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh
Siu Fung Stanley Ho
Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom
Robert A. Moran
Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom
John D. Clemens
The Laboratory of Food Safety and One Health, Laboratory Sciences and Services Division, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh
Md Sirajul Islam
The Laboratory of Food Safety and One Health, Laboratory Sciences and Services Division, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh
Willem van Schaik
Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom
Low- and middle-income countries (LMICs) have higher burdens of multidrug-resistant infections than high-income countries, and there is thus an urgent need to elucidate the drivers of the spread of antibiotic-resistant bacteria in LMICs. Here, we study the diversity and abundance of antibiotic resistance genes in surface water and sediments from rural and urban settings in Bangladesh.
