Fetal-derived macrophages dominate in adult mammary glands

Norma Jäppinen; Inês Félix; Emmi Lokka; Sofia Tyystjärvi; Anne Pynttäri; Tiina Lahtela; Heidi Gerke; Kati Elima; Pia Rantakari; Marko Salmi

doi:10.1038/s41467-018-08065-1

Nature Communications (Jan 2019)

Fetal-derived macrophages dominate in adult mammary glands

Norma Jäppinen,
Inês Félix,
Emmi Lokka,
Sofia Tyystjärvi,
Anne Pynttäri,
Tiina Lahtela,
Heidi Gerke,
Kati Elima,
Pia Rantakari,
Marko Salmi

Affiliations

Norma Jäppinen: Institute of Biomedicine, University of Turku
Inês Félix: Institute of Biomedicine, University of Turku
Emmi Lokka: Institute of Biomedicine, University of Turku
Sofia Tyystjärvi: Institute of Biomedicine, University of Turku
Anne Pynttäri: Institute of Biomedicine, University of Turku
Tiina Lahtela: Institute of Biomedicine, University of Turku
Heidi Gerke: Institute of Biomedicine, University of Turku
Kati Elima: Institute of Biomedicine, University of Turku
Pia Rantakari: Institute of Biomedicine, University of Turku
Marko Salmi: Institute of Biomedicine, University of Turku

DOI: https://doi.org/10.1038/s41467-018-08065-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

Read online

Tissue-resident macrophages are highly specialized phagocytes that serve multiple functions. Here, using high-dimension analyses and fate-mapping experiments, the authors show that fetal liver-derived macrophages dominate the mammary gland in neonatal and adult, and display characteristic phenotypes and functions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal