Evaluation of Motor Neuron Excitability by CMAP Scanning with Electric Modulated Current

Neuroscience Journal. 2015;2015 DOI 10.1155/2015/360648

 

Journal Homepage

Journal Title: Neuroscience Journal

ISSN: 2314-4262 (Print); 2314-4270 (Online)

Publisher: Hindawi Limited

LCC Subject Category: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry

Country of publisher: United Kingdom

Language of fulltext: English

Full-text formats available: PDF, HTML, ePUB, XML

 

AUTHORS

Tiago Araújo (Department of Physics, Faculty of Sciences and Technology, New University of Lisbon, Lisbon, Portugal)
Rui Candeias (Department of Physics, Faculty of Sciences and Technology, New University of Lisbon, Lisbon, Portugal)
Neuza Nunes (PLUX Wireless Biosignals S.A., Lisbon, Portugal)
Hugo Gamboa (Department of Physics, Faculty of Sciences and Technology, New University of Lisbon, Lisbon, Portugal)

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 14 weeks

 

Abstract | Full Text

Introduction. Compound Muscle Action Potential (CMAP) scan is a noninvasive promissory technique for neurodegenerative pathologies diagnosis. In this work new CMAP scan protocols were implemented to study the influence of electrical pulse waveform on peripheral nerve excitability. Methods. A total of 13 healthy subjects were tested. Stimulation was performed with an increasing intensities range from 4 to 30 mA. The procedure was repeated 4 times per subject, using a different single pulse stimulation waveform: monophasic square and triangular and quadratic and biphasic square. Results. Different waveforms elicit different intensity-response amplitude curves. The square pulse needs less current to generate the same response amplitude regarding the other waves and this effect is gradually decreasing for the triangular, quadratic, and biphasic pulse, respectively. Conclusion. The stimulation waveform has a direct influence on the stimulus-response slope and consequently on the motoneurons excitability. This can be a new prognostic parameter for neurodegenerative disorders.