Comparison of two commercial cyclosporin assays

Abstract

A new Dade Behring Cyclosporin A (CsA) assay has been made commercially accessible recently. The aim of this study was to examine the analytical performance of this assay and the correlation with the Abbott Diagnostics assay. The accuracy and precision within-run were good, but precision between-run slightly exceeded the manufacturer's recommendation on one quality-control material. Dade Behring CsA whole blood results from the kidney recipients (n = 104) were lower (p < 0.001) than the Abbott results. The correlation between these two assays was significant (y = -15.61 0.751x; r= 0.974; p < 0.001). Dade Behring CsA assay demonstrates adequate performance characteristics for routine clinical use and the main advantage is the full automatization without the need for samples pretreatment.

Keywords

• abbott diagnostics assay
• correlation
• cyclosporin a
• dade behring assay
• transplantation