Pseudomonas aeruginosa Takes a Multi-Target Approach to Achieve Junction Breach

Abstract

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Pseudomonas aeruginosa is an opportunistic pathogen which uses a number of strategies to cross epithelial and endothelial barriers at cell–cell junctions. In this review, we describe how the coordinated actions of P. aeruginosa's virulence factors trigger various molecular mechanisms to disarm the junctional gate responsible for tissue integrity.

Keywords

• bacterial invasion
• bacterial virulence factors
• intercellular junctions
• bacterial secretion systems
• epithelium
• endothelium