BMC Endocrine Disorders (Jun 2022)

Implications of regulator of G-protein signaling 5 expression in the pathogenesis of primary and secondary hyperparathyroidism

  • Xin Li,
  • Yao Lu,
  • Ling Zhang,
  • Aiping Song,
  • Honglei Zhang,
  • Bo Pang,
  • Jun Liu,
  • Xiaoliang Sun,
  • Haoyang Ji,
  • Linping Huang,
  • Meng Yang

DOI
https://doi.org/10.1186/s12902-022-01066-8
Journal volume & issue
Vol. 22, no. 1
pp. 1 – 6

Abstract

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Abstract Objective To study the protein and mRNA expressions of regulator of G-protein signaling 5 (RGS5) in the pathogenesis of hyperparathyroidism. Methods The expression of RGS5 protein in 20 primary hyperparathyroidism (PHPT), 31 secondary hyperparathyroidism (SHPT), and 20 control cases were studied by immunohistochemistry (IHC). The expression of RGS5 mRNA in 15 PHPT, 102 SHPT, and 7 normal parathyroid tissue were measured by quantitative real-time PCR (qRT-PCR) method. Results The expressions of RGS5 in PHPT tissues were significantly higher than that in SHPT and normal parathyroid tissues (P 0.05). Likewise, the RGS5 mRNA expression in PHPT was significantly higher than that in SHPT (P 0.05). Conclusions The characteristic RGS5 protein and mRNA levels in hyperparathyroidism might be helpful in discovering the pathomechanism of hyperparathyroidism and novel therapeutic targets as well.