Combination of antifungal agent and prebiotic for acute vulvovaginal candidiasis

Abstract

Combination of antifungal agent and prebiotic for acute vulvovaginal candidiasis P.N. Krotin, O.V. Kirilenko City Consultative Diagnostic Center “Juventa”, St. Petersburg, Russian Federation Aim: To assess efficacy and safety of Ecofucin® vaginal suppositories based on the time to clinical and microbiological remission in women with acute vaginal or vulvovaginal candidiasis. Patients and Methods: The study enrolled women aged 18–45 with acute vaginal or vulvovaginal candidiasis. All patients were subdivided into 2 groups. Study group included 36 patients who received Ecofucin® vaginal suppositories (natamycin 100 mg plus lactulose 300 mg) once a day for 6 days. Control group included 36 patients who received Pimafucin® vaginal suppositories (natamycin 100 mg) once a day for 6 days. Efficacy and safety of medications were assessed by gynecological examination, laboratory tests, and patient diaries. Follow-up examinations were performed at days 4, 7, and 37 (±2 days) after treatment begins (30±2 days after treatment finishes). Results: Combination of antifungal medication (natamycin) and prebiotic in a vaginal suppository provides more rapid clinical remission and complete elimination of VVC causative agent thus resulting in active growth of lactobacilli, principal competitors of yeasts in vaginal microbiocoenosis. Conclusions: Good tolerability of Ecofucin® was demonstrated, no adverse reactions were reported. Keywords: vulvovaginal candidiasis, vaginal microbiocoenosis, lactobacilli. For citation: Krotin P.N., Kirilenko O.V. Combination of antifungal agent and prebiotic for acute vulvovaginal candidiasis. Russian Journal of Woman and Child Health. 2019;2(2):120–125.