Cytokine and Toll-like receptor gene polymorphisms as predisposition factors for polyposis rhinosinusitis (a review of literature)

Abstract

Polyposis rhinosinusitis (PRS) is a complex multifactorial disease. Genetic factors have been shown to predispose to the development of this pathology. Cytokines and disorders of Toll-like receptors play a significant role in the pathogenesis of HRP. Therefore, the identification of polymorphic variants of immune system genes that can be predictors of the disease development risk is a promising direction. This paper analyzes scientific articles on the role of expression and gene polymorphism of the most important cytokines and Toll-like receptors in the association with the predisposition and the course of this pathology. It is believed that genetic markers of HRS are important in predicting the risk of disease development, its course and the effectiveness of the therapy.

Keywords

• polyposis rhinosinusitis
• molecular genetic markers
• cytokines
• toll-like receptors
• genes
• polymophysis