Бюллетень сибирской медицины (Dec 2012)

Antigenic properties estimation for legumain protein recombinant analogue of trematoda Opisthorchis felineus, causing human opisthorchiasis

  • I. A. Razumov,
  • M. N. Lvova,
  • Ye. P. Ponomareva,
  • A. V. Katokhin,
  • V. A. Petrenko,
  • A. E. Sazonov,
  • L. M. Ogorodova,
  • V. V. Novitsky,
  • A. Yu. Sivkov,
  • V. A. Mordvinov

DOI
https://doi.org/10.20538/1682-0363-2012-6-166-171
Journal volume & issue
Vol. 11, no. 6
pp. 166 – 171

Abstract

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We estimated potential of protein legumain from opisthorchiasis agent O. felineus for application in immunodiagnosis of this disease. Bacterially expressed recombinant protein (rOF49-leg) showed strong difference in Enzyme-linked immunosorbent assay (ELISA) between infected and negative sera. These results suggest the potential of this antigen for development of serodiagnostic test for human opisthorchiasis.

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