Ataxia-telangiectasia Mutated Kinase (ATM) as a Central Regulator of Radiation-induced DNA Damage Response
Aleš Tichý,
Jiřina Vávrová,
Jaroslav Pejchal,
Martina Řezáčová
Affiliations
Aleš Tichý
Charles University in Praha, Faculty of Medicine and University Hospital Hradec Králové, Department of Medical Biochemistry, Hradec Králové, Czech Republic; University of Defence in Brno, Faculty of Military Health Sciences in Hradec Králové, Department of Radiobiology, Hradec Králové, Czech Republic
Jiřina Vávrová
University of Defence in Brno, Faculty of Military Health Sciences in Hradec Králové, Department of Radiobiology, Hradec Králové, Czech Republic
Jaroslav Pejchal
University of Defence in Brno, Faculty of Military Health Sciences in Hradec Králové, Centre of Advanced Studies, Hradec Králové, Czech Republic
Martina Řezáčová
Charles University in Praha, Faculty of Medicine and University Hospital Hradec Králové, Department of Medical Biochemistry, Hradec Králové, Czech Republic
Ataxia-telangiectasia mutated kinase (ATM) is a DNA damage-inducible protein kinase, which phosphorylates plethora of substrates participating in DNA damage response. ATM significance for the cell faith is undeniable, since it regulates DNA repair, cell-cycle progress, and apoptosis. Here we describe its main signalling targets and discuss its importance in DNA repair as well as novel findings linked to this key regulatory enzyme in the terms of ionizing radiationinduced DNA damage.
