Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer

Shih-Chieh Lin; Chung-Yang Kao; Hui-Ju Lee; Chad J. Creighton; Michael M. Ittmann; Shaw-Jenq Tsai; Sophia Y. Tsai; Ming-Jer Tsai

doi:10.1038/ncomms11418

Nature Communications (Apr 2016)

Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer

Shih-Chieh Lin,
Chung-Yang Kao,
Hui-Ju Lee,
Chad J. Creighton,
Michael M. Ittmann,
Shaw-Jenq Tsai,
Sophia Y. Tsai,
Ming-Jer Tsai

Affiliations

Shih-Chieh Lin: Department of Molecular and Cellular Biology, Baylor College of Medicine
Chung-Yang Kao: Department of Molecular and Cellular Biology, Baylor College of Medicine
Hui-Ju Lee: Department of Molecular and Cellular Biology, Baylor College of Medicine
Chad J. Creighton: Department of Medicine, Dan L. Duncan Cancer Center Division of Biostatistics, Baylor College of Medicine
Michael M. Ittmann: Department of Pathology and Immunology, Baylor College of Medicine
Shaw-Jenq Tsai: Department of Physiology, College of Medicine, National Cheng Kung University
Sophia Y. Tsai: Department of Molecular and Cellular Biology, Baylor College of Medicine
Ming-Jer Tsai: Department of Molecular and Cellular Biology, Baylor College of Medicine

DOI: https://doi.org/10.1038/ncomms11418
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

Read online

The orphan nuclear receptor COUP-TFII is highly expressed in metastatic prostate cancers and its overexpression accelerates prostate tumour progression in mouse models. Here, the author show that that loss of miR-101 and miR-27a in prostate cancer cells can lead to COUP-TFII expression which in turn directly regulates FOXM1 and CENPFfavouring prostate cancer metastasis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal