Understanding the Reaction Crystallization Process of Glycidyl Trimethyl Ammonium Chloride
Shuai Yu,
Hui Chen,
Xujie Gao,
Weichun Feng,
Wenguo Xing,
Shichao Du,
Yan Wang,
Fumin Xue,
Yan Cheng
Affiliations
Shuai Yu
Shandong Analysis and Test Center, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China
Hui Chen
Shandong Analysis and Test Center, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China
Xujie Gao
Shandong Analysis and Test Center, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China
Weichun Feng
Chemical Technology Research Institute of Shandong, Qingdao University of Science & Technology, Jinan 250014, China
Wenguo Xing
Chemical Technology Research Institute of Shandong, Qingdao University of Science & Technology, Jinan 250014, China
Shichao Du
Shandong Analysis and Test Center, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China
Yan Wang
Shandong Analysis and Test Center, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China
Fumin Xue
Shandong Analysis and Test Center, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China
Yan Cheng
Shandong Analysis and Test Center, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China
Reaction crystallization to produce glycidyl trimethyl ammonium chloride (GTA) via epichlorohydrin with gas-state trimethylamine was investigated. The crystallization process of the GTA gas-liquid reaction was optimized by a seed method. The optimized technology can prepare GTA products with crystal form and purity greater than 97%. The crystallization process of GTA consists of four steps (i.e., addition of seed, dispersion of seed, growth of crystals on the seed surfaces, agglomeration and growth of crystal). Seed method and flow rate are the key factors affecting purity. The purity and particle size of GTA crystals were satisfactory as long as the operation was kept within the defined envelope. The experiments were conducted on a 1 L reactor and successfully scaled-up to 3000 L in industry.
