The role of Sirtuin 1 and its activators in age-related lung disease

Chaoqun Sun; Shuyou Bai; Yanmei Liang; Dewei Liu; Jinyu Liao; Yujuan Chen; Xuanna Zhao; Bin Wu; Dan Huang; Min Chen; Dong Wu

Biomedicine & Pharmacotherapy (Jun 2023)

The role of Sirtuin 1 and its activators in age-related lung disease

Chaoqun Sun,
Shuyou Bai,
Yanmei Liang,
Dewei Liu,
Jinyu Liao,
Yujuan Chen,
Xuanna Zhao,
Bin Wu,
Dan Huang,
Min Chen,
Dong Wu

Affiliations

Chaoqun Sun: Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, China
Shuyou Bai: Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, China
Yanmei Liang: Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, China
Dewei Liu: Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, China
Jinyu Liao: Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, China
Yujuan Chen: Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, China
Xuanna Zhao: Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, China
Bin Wu: Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, China
Dan Huang: Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, China; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa 999078, Macao Special Administrative Region of China; Correspondence to: Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, 57 South Renmin Road, Zhanjiang 524001, China.
Min Chen: Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, China
Dong Wu: Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, China

Journal volume & issue: Vol. 162
p. 114573

Abstract

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Aging is a major driving factor in lung diseases. Age-related lung disease is associated with downregulated expression of SIRT1, an NAD+-dependent deacetylase that regulates inflammation and stress resistance. SIRT1 acts by inducing the deacetylation of various substrates and regulates several mechanisms that relate to lung aging, such as genomic instability, lung stem cell exhaustion, mitochondrial dysfunction, telomere shortening, and immune senescence. Chinese herbal medicines have many biological activities, exerting anti-inflammatory, anti-oxidation, anti-tumor, and immune regulatory effects. Recent studies have confirmed that many Chinese herbs have the effect of activating SIRT1. Therefore, we reviewed the mechanism of SIRT1 in age-related lung disease and explored the potential roles of Chinese herbs as SIRT1 activators in the treatment of age-related lung disease.

Published in Biomedicine & Pharmacotherapy

ISSN: 0753-3322 (Print); 1950-6007 (Online)
Publisher: Elsevier
Country of publisher: France
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.journals.elsevier.com/biomedicine-and-pharmacotherapy

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Abstract

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