Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau

Rebecca Freilich; Miguel Betegon; Eric Tse; Sue-Ann Mok; Olivier Julien; David A. Agard; Daniel R. Southworth; Koh Takeuchi; Jason E. Gestwicki

doi:10.1038/s41467-018-07012-4

Nature Communications (Nov 2018)

Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau

Rebecca Freilich,
Miguel Betegon,
Eric Tse,
Sue-Ann Mok,
Olivier Julien,
David A. Agard,
Daniel R. Southworth,
Koh Takeuchi,
Jason E. Gestwicki

Affiliations

Rebecca Freilich: Department of Pharmaceutical Chemistry, University of California San Francisco
Miguel Betegon: Department of Biochemistry and Biophysics, University of California San Francisco
Eric Tse: Department of Biochemistry and Biophysics, University of California San Francisco
Sue-Ann Mok: Department of Pharmaceutical Chemistry, University of California San Francisco
Olivier Julien: Department of Pharmaceutical Chemistry, University of California San Francisco
David A. Agard: Department of Biochemistry and Biophysics, University of California San Francisco
Daniel R. Southworth: Department of Biochemistry and Biophysics, University of California San Francisco
Koh Takeuchi: Molecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST)
Jason E. Gestwicki: Department of Pharmaceutical Chemistry, University of California San Francisco

DOI: https://doi.org/10.1038/s41467-018-07012-4
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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Small heat shock proteins (sHSPs) limit the aggregation of proteins, such as tau. Here the authors show that Hsp27 recognizes two aggregation-prone regions of tau and that this interaction competes with Hsp27 oligomerization.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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