Медицинская иммунология (Jul 2014)

THE PHENOTYPE AND FUNCTION OF MONOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS

  • L. V. Sakhno,
  • M. A. Tihonova,
  • V. S. Kozhevnikov,
  • V. V. Senjukov,
  • N. V. Pronkina,
  • S. D. Nikonov,
  • O. A. Zhdanov,
  • A. A. Ostanin,
  • E. R. Chernykh

DOI
https://doi.org/10.15789/1563-0625-2005-1-49-56
Journal volume & issue
Vol. 7, no. 1
pp. 49 – 56

Abstract

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Abstract. Peripheral blood monocytes were investigated in the patients with pulmonary tuberculosis. It was established that population of CD14+16+ monocytes was twofold increased in the patients with tuberculosis. The higher level of CD14+CD16+ monocytes was associated with decreasing number of monocytes with intracellular TNF–α, and negative correlation between these parameters was revealed. On the contrary, the higher level of CD14+CD16+ monocytes was connected with increased number of IL–10–producing monocytes. IL–10–producing cells were established mainly in the population of CD16+ monocytes and so population of CD14+CD16+ monocytes may represent the cells with suppressive activity. Really, the CD14+CD16+ monocytes were increased in patients with defective antigen specific response. Enhancement of CD14+CD16+ monocytes was observed in patients with active tuberculosis independently of form and dissemination of disease and did not connected with concomitant viral or bacterial infection. (Med. Immunol., 2005, vol.7, № 1, pp 49556)

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