lncRNA transcription induces meiotic recombination through chromatin remodelling in fission yeast

Abstract

Senmatsu et al. show that transcription of long-noncoding RNAs (lncRNA) previously identified in the fission yeast fbp1 gene and found to induce chromatin opening, also activates meiotic recombination by inducing local chromatin remodeling at a meiotic recombination hotspot. This study furthers our understanding of the connection between lncRNA transcription and DNA break activity in yeast meiosis.