Jouvence a small nucleolar RNA required in the gut extends lifespan in Drosophila

Stéphanie Soulé; Lucille Mellottée; Abdelkrim Arab; Chongjian Chen; Jean-René Martin

doi:10.1038/s41467-020-14784-1

Nature Communications (Feb 2020)

Jouvence a small nucleolar RNA required in the gut extends lifespan in Drosophila

Stéphanie Soulé,
Lucille Mellottée,
Abdelkrim Arab,
Chongjian Chen,
Jean-René Martin

Affiliations

Stéphanie Soulé: Institut des Neurosciences Paris-Saclay (Neuro-PSI), UMR-9197, Equipe: Imagerie Cérébrale Fonctionnelle et Comportements (ICFC), CNRS/Université Paris Sud
Lucille Mellottée: Institut des Neurosciences Paris-Saclay (Neuro-PSI), UMR-9197, Equipe: Imagerie Cérébrale Fonctionnelle et Comportements (ICFC), CNRS/Université Paris Sud
Abdelkrim Arab: Institut des Neurosciences Paris-Saclay (Neuro-PSI), UMR-9197, Equipe: Imagerie Cérébrale Fonctionnelle et Comportements (ICFC), CNRS/Université Paris Sud
Chongjian Chen: Genetics and Developmental Biology Department, Mammalian Developmental Epigenetics Group (E. Heard Lab.), Institut Curie, CNRS UMR-3215
Jean-René Martin: Institut des Neurosciences Paris-Saclay (Neuro-PSI), UMR-9197, Equipe: Imagerie Cérébrale Fonctionnelle et Comportements (ICFC), CNRS/Université Paris Sud

DOI: https://doi.org/10.1038/s41467-020-14784-1
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 21

Abstract

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Small non-coding RNAs contribute to the regulation of aging. Here the authors identify a small nucleolar RNA, the snoRNA jouvence, which extends the lifespan of fruit flies through its function in the gut, and is conserved in humans.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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