A Comprehensive Review Of 2016 Gleason’s Criteria For Scoring Of Prostate Adenocarcinoma

Abstract

Gleason’s scoring system was introduced by Dr. Donald Gleason in 1960 and till date it is widely accepted to score the prostate adenocarcinoma. This remained the best predictor for treatment and prognosis of the patients. This system depends upon the histological features of the prostate adenocarcinoma and morphological patterns. The most common and second most common patterns identified on biopsy are used to be added up to score the prostate adenocarcinomas. However, certain limitations, in particular to scores; 7, 8 and 9 along with Gleason’s relation to tumor variants, is having a large impact on prognosis and course of treatment. To overcome these limitations, John Hopkins university proposed a new scoring system for the prostate adenocarcinoma in 2013, consisting of 5 grade groups. Grade Group 1=Gleason score≤6, Grade Group 2=Gleason score 3+4=7, Grade Group 3=Gleason score 4+3=7, Grade Group 4=Gleason score 4+4=8, Grade Group 5=Gleason scores 9 and 10. The updated grade groups provide proper scoring for the prostate adenocarcinoma to address the present limitations. Key Words: Prostate cancer, Grading, Prognosis, Gleason grade.