Journal of Multidisciplinary Healthcare (May 2022)

Time to Death and Predictors Among Neonates with Esophageal Atresia in Ethiopia

  • Misganaw NM,
  • Sebsbie G,
  • Adimasu M,
  • Getaneh FB,
  • Arage G,
  • GebreEyesus FA,
  • Bayih WA,
  • Chanie ES,
  • Bantie B,
  • Kerebeh G,
  • Birhanu D,
  • Jemere T,
  • Mengist A,
  • Kassaw A

Journal volume & issue
Vol. Volume 15
pp. 1225 – 1235

Abstract

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Natnael Moges Misganaw,1 Girum Sebsbie,2 Mekonen Adimasu,2 Fekadeselassie Belege Getaneh,3 Getachew Arage,1 Fisha Alebel GebreEyesus,4 Wubet Alebachew Bayih,1 Ermias Sisay Chanie,1 Berihun Bantie,5 Gashaw Kerebeh,1 Dires Birhanu,6 Tadeg Jemere,7 Anteneh Mengist,8 Amare Kassaw1 1Debre Tabor University, College of Health Science, Department of Paediatrics and Child Health Nursing, Debre Tabor, Ethiopia; 2Addis Ababa University, College of Health Science, School of Nursing and Midwifery, Department of Paediatrics and Child Health Nursing, Addis Ababa, Ethiopia; 3Wollo University, College of Health Science, School of Nursing and Midwifery, Department of Paediatrics and Child Health Nursing, Dessie, Ethiopia; 4Wolkite University, College of Medicine and Health Science, Department of Paediatrics and Child Health Nursing, Wolkite, Ethiopia; 5Debre Tabor University, College of Health Science, Department of Adult Health Nursing, Debre Tabor, Ethiopia; 6Dilla University, College of Health Science, Department of Paediatrics and Child Health Nursing, Dilla, Ethiopia; 7Debre Tabor University, College of Health Science, Department of Biomedical Science, Debre Tabor, Ethiopia; 8Debre Tabor University, College of Health Science, Department of Public Health, Debre Tabor, EthiopiaCorrespondence: Natnael Moges Misganaw, Email [email protected]: Esophageal atresia is an upper gastrointestinal tract developmental abnormality in which the upper and lower esophagus do not connect. Esophageal atresia has a higher incidence of death in sub-Saharan Africa, ranging from 30% to 80%. In Ethiopia, infants with esophageal atresia had a higher mortality rate. The assessment of time to death and predictors of esophageal atresia can help to reduce newborn mortality.Objective: This study was aimed to investigate the time to death and predictors of neonates with esophageal atresia admitted to Tikur Anbessa Specialized Hospital, Ethiopia.Methods: An institutional-based retrospective follow-up study was conducted among 225 neonates diagnosed with esophageal atresia. The median survival time, Kaplan–Meier failure estimation curve, and Log rank test were computed. Bivariable and multivariable Cox regression hazards models were fitted to identify the predictors of time to death. Hazard ratio with a 95% confidence interval was calculated and p-values 48 hours of admission (AHR = 1.48, 95% CI, 1.01– 2.15) and being dehydrated (AHR = 2.38, 95% CI, 1.63– 3.46) were significant predictors of time to death among esophageal atretic neonates.Conclusion: The findings in this study highlighted the necessity of early diagnosis, proper comorbidity treatment, and timely surgical intervention to reduce infant deaths due to esophageal atresia.Keywords: esophageal atresia, time to death, Ethiopia

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