Nature Communications (Jul 2022)
Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling
- Shouya Feng,
- Daniel Enosi Tuipulotu,
- Abhimanu Pandey,
- Weidong Jing,
- Cheng Shen,
- Chinh Ngo,
- Melkamu B. Tessema,
- Fei-Ju Li,
- Daniel Fox,
- Anukriti Mathur,
- Anyang Zhao,
- Runli Wang,
- Klaus Pfeffer,
- Daniel Degrandi,
- Masahiro Yamamoto,
- Patrick C. Reading,
- Gaetan Burgio,
- Si Ming Man
Affiliations
- Shouya Feng
- Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University
- Daniel Enosi Tuipulotu
- Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University
- Abhimanu Pandey
- Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University
- Weidong Jing
- Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University
- Cheng Shen
- Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University
- Chinh Ngo
- Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University
- Melkamu B. Tessema
- Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity
- Fei-Ju Li
- Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University
- Daniel Fox
- Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University
- Anukriti Mathur
- Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University
- Anyang Zhao
- Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University
- Runli Wang
- Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University
- Klaus Pfeffer
- Institute of Medical Microbiology and Hospital Hygiene, Heinrich-Heine-University Düsseldorf
- Daniel Degrandi
- Institute of Medical Microbiology and Hospital Hygiene, Heinrich-Heine-University Düsseldorf
- Masahiro Yamamoto
- Department of Immunoparasitology, Research Institute for Microbial Diseases, Osaka University
- Patrick C. Reading
- Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity
- Gaetan Burgio
- Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University
- Si Ming Man
- Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University
- DOI
- https://doi.org/10.1038/s41467-022-32127-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Guanylate-binding proteins (GBP) have a function in inflammasome formation and pathogen defence. Here the authors show that these GBP proteins are able to kill certain bacteria and promote selective inflammasome activation and that this is mediated by specific GBP protein regions.
