Structure of the heterotrimeric membrane protein complex FtsB-FtsL-FtsQ of the bacterial divisome

Hong Thuy Vy Nguyen; Xiaorui Chen; Claudia Parada; An-Chi Luo; Orion Shih; U-Ser Jeng; Chia-Ying Huang; Yu-Ling Shih; Che Ma

doi:10.1038/s41467-023-37543-4

Nature Communications (Apr 2023)

Structure of the heterotrimeric membrane protein complex FtsB-FtsL-FtsQ of the bacterial divisome

Hong Thuy Vy Nguyen,
Xiaorui Chen,
Claudia Parada,
An-Chi Luo,
Orion Shih,
U-Ser Jeng,
Chia-Ying Huang,
Yu-Ling Shih,
Che Ma

Affiliations

Hong Thuy Vy Nguyen: Genomics Research Center, Academia Sinica
Xiaorui Chen: Genomics Research Center, Academia Sinica
Claudia Parada: Institute of Biological Chemistry, Academia Sinica
An-Chi Luo: Institute of Biochemical Sciences, National Taiwan University
Orion Shih: National Synchrotron Radiation Research Center
U-Ser Jeng: National Synchrotron Radiation Research Center
Chia-Ying Huang: Paul Scherrer Institute
Yu-Ling Shih: Institute of Biochemical Sciences, National Taiwan University
Che Ma: Genomics Research Center, Academia Sinica

DOI: https://doi.org/10.1038/s41467-023-37543-4
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 13

Abstract

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The FtsB-FtsL-FtsQ complex is essential for regulating cell wall synthesis during bacterial cell division. Here, authors report the full-length trimeric structure showing a tilted V-shaped conformation and suggest an allosteric regulatory mechanism.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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