Frontiers in Neurology (Apr 2021)
An Analysis of the Potential Relationship of Triglyceride Glucose and Body Mass Index With Stroke Prognosis
- Zongyi Hou,
- Zongyi Hou,
- Yuesong Pan,
- Yuesong Pan,
- Yuesong Pan,
- Yuesong Pan,
- Yindong Yang,
- Yindong Yang,
- Xiaofan Yang,
- Xiaofan Yang,
- Xianglong Xiang,
- Xianglong Xiang,
- Xianglong Xiang,
- Xianglong Xiang,
- Yilong Wang,
- Yilong Wang,
- Yilong Wang,
- Yilong Wang,
- Zixiao Li,
- Zixiao Li,
- Zixiao Li,
- Zixiao Li,
- Xingquan Zhao,
- Xingquan Zhao,
- Xingquan Zhao,
- Xingquan Zhao,
- Hao Li,
- Hao Li,
- Hao Li,
- Hao Li,
- Xia Meng,
- Xia Meng,
- Xia Meng,
- Xia Meng,
- Yongjun Wang,
- Yongjun Wang,
- Yongjun Wang,
- Yongjun Wang
Affiliations
- Zongyi Hou
- Department of Neurology, Hongqi Hospital, Mudanjiang Medical University, Mudanjiang, China
- Zongyi Hou
- Heilongjiang Key Laboratory of Ischemic Stroke Prevention and Treatment, Mudanjiang, China
- Yuesong Pan
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Yuesong Pan
- China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Yuesong Pan
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Yuesong Pan
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Yindong Yang
- Department of Neurology, Hongqi Hospital, Mudanjiang Medical University, Mudanjiang, China
- Yindong Yang
- Heilongjiang Key Laboratory of Ischemic Stroke Prevention and Treatment, Mudanjiang, China
- Xiaofan Yang
- Department of Neurology, Hongqi Hospital, Mudanjiang Medical University, Mudanjiang, China
- Xiaofan Yang
- Heilongjiang Key Laboratory of Ischemic Stroke Prevention and Treatment, Mudanjiang, China
- Xianglong Xiang
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Xianglong Xiang
- China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Xianglong Xiang
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Xianglong Xiang
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Yilong Wang
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Yilong Wang
- China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Yilong Wang
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Yilong Wang
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Zixiao Li
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Zixiao Li
- China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Zixiao Li
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Zixiao Li
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Xingquan Zhao
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Xingquan Zhao
- China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Xingquan Zhao
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Xingquan Zhao
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Hao Li
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Hao Li
- China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Hao Li
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Hao Li
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Xia Meng
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Xia Meng
- China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Xia Meng
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Xia Meng
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Yongjun Wang
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Yongjun Wang
- China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Yongjun Wang
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Yongjun Wang
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- DOI
- https://doi.org/10.3389/fneur.2021.630140
- Journal volume & issue
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Vol. 12
Abstract
Background: The inverse association between obesity and outcome in stroke patients (known as the obesity paradox) has been widely reported, yet mechanistic details explaining the paradox are limited. The triglyceride glucose (TYG) index has been proposed as a marker of insulin resistance. We sought to explore possible associations of the TYG index, body mass index (BMI), and stroke outcome.Methods: We identified 12,964 ischemic stroke patients without a history of diabetes mellitus from the China National Stroke Registry and classified patients as either low/normal weight, defined as a BMI <25 kg/m2, or overweight/obese, defined as a BMI ≥ 25 kg/m2. We calculated TYG index and based on which the patients were divided into four groups. A Cox or logistic regression model was used to evaluate the association between BMI and TYG index and its influence on stroke outcomes, including stroke recurrence all-cause mortality and poor outcome (modified Rankin Scale score of 3–6) at 12 months.Results: Among the patients, 63.3% were male, and 36.7% were female, and the mean age of the patient cohort was 64.8 years old. The median TYG index was 8.62 (interquartile range, 8.25–9.05). After adjusting for multiple potential covariates, the all-cause mortality of overweight/obese patients was significantly lower than that of the low/normal weight patients (6.17 vs. 9.32%; adjusted hazard ratio, 0.847; 95% CI 0.732–0.981). The difference in mortality in overweight/obese and low/normal weight patients with ischemic stroke was not associated with TYG index, and no association between BMI and TYG index was found.Conclusion: Overweight/obese patients with ischemic stroke have better survival than patients with low/normal weight. The association of BMI and stroke outcome is not changed by TYG index.
Keywords