Nature Communications (Jan 2020)
Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis
- Franziska Herster,
- Zsofia Bittner,
- Nathan K. Archer,
- Sabine Dickhöfer,
- David Eisel,
- Tatjana Eigenbrod,
- Thomas Knorpp,
- Nicole Schneiderhan-Marra,
- Markus W. Löffler,
- Hubert Kalbacher,
- Tim Vierbuchen,
- Holger Heine,
- Lloyd S. Miller,
- Dominik Hartl,
- Lukas Freund,
- Knut Schäkel,
- Martin Heister,
- Kamran Ghoreschi,
- Alexander N. R. Weber
Affiliations
- Franziska Herster
- Department of Immunology, University of Tübingen
- Zsofia Bittner
- Department of Immunology, University of Tübingen
- Nathan K. Archer
- Department of Dermatology, Johns Hopkins University School of Medicine
- Sabine Dickhöfer
- Department of Immunology, University of Tübingen
- David Eisel
- Department of Immunology, University of Tübingen
- Tatjana Eigenbrod
- Department of Infectious Diseases, Medical Microbiology and Hygiene, University Hospital Heidelberg
- Thomas Knorpp
- NMI Natural and Medical Sciences Institute at the University of Tübingen
- Nicole Schneiderhan-Marra
- NMI Natural and Medical Sciences Institute at the University of Tübingen
- Markus W. Löffler
- Department of Immunology, University of Tübingen
- Hubert Kalbacher
- Interfaculty Institute of Biochemistry, University of Tübingen
- Tim Vierbuchen
- Research Group Innate Immunity, Research Center Borstel, Leibniz Lung Center, Airway Research Center North (ARCN), Deutsches Zentrum für Lungenforschung (DZL)
- Holger Heine
- Research Group Innate Immunity, Research Center Borstel, Leibniz Lung Center, Airway Research Center North (ARCN), Deutsches Zentrum für Lungenforschung (DZL)
- Lloyd S. Miller
- Department of Dermatology, Johns Hopkins University School of Medicine
- Dominik Hartl
- University Children’s Hospital and Interdisciplinary Center for Infectious Diseases, University of Tübingen
- Lukas Freund
- Department of Dermatology, University Hospital Heidelberg
- Knut Schäkel
- Department of Dermatology, University Hospital Heidelberg
- Martin Heister
- Department of Dermatology, University Hospital Tübingen
- Kamran Ghoreschi
- Department of Dermatology, University Hospital Tübingen
- Alexander N. R. Weber
- Department of Immunology, University of Tübingen
- DOI
- https://doi.org/10.1038/s41467-019-13756-4
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Antimicrobial peptide LL37 can bind nucleic acids and potentiate their sensing by endosomal TLRs. Here the authors show that LL37 binds to RNA from neutrophil extracellular traps (NETs), which amplifies inflammation and production of more LL37 and NETs via TLR8/13, suggesting that LL37 contribution to psoriasis may be fueled by NET-associated RNA.
