Established and Emerging Regulatory Roles of Eukaryotic Translation Initiation Factor 5B (eIF5B)

Prakash Amruth Raj Chukka; Prakash Amruth Raj Chukka; Prakash Amruth Raj Chukka; Prakash Amruth Raj Chukka; Stacey D. Wetmore; Stacey D. Wetmore; Stacey D. Wetmore; Stacey D. Wetmore; Nehal Thakor; Nehal Thakor; Nehal Thakor; Nehal Thakor; Nehal Thakor

doi:10.3389/fgene.2021.737433

Frontiers in Genetics (Aug 2021)

Established and Emerging Regulatory Roles of Eukaryotic Translation Initiation Factor 5B (eIF5B)

Prakash Amruth Raj Chukka,
Prakash Amruth Raj Chukka,
Prakash Amruth Raj Chukka,
Prakash Amruth Raj Chukka,
Stacey D. Wetmore,
Stacey D. Wetmore,
Stacey D. Wetmore,
Stacey D. Wetmore,
Nehal Thakor,
Nehal Thakor,
Nehal Thakor,
Nehal Thakor,
Nehal Thakor

Affiliations

Prakash Amruth Raj Chukka: Department of Chemistry and Biochemistry, University of Lethbridge, Lethbridge, AB, Canada
Prakash Amruth Raj Chukka: Southern Alberta Genome Sciences Centre (SAGSC), University of Lethbridge, Lethbridge, AB, Canada
Prakash Amruth Raj Chukka: Alberta RNA Research and Training Institute (ARRTI), University of Lethbridge, Lethbridge, AB, Canada
Prakash Amruth Raj Chukka: Canadian Centre of Research in Advanced Fluorine Technologies (C-CRAFT), University of Lethbridge, Lethbridge, AB, Canada
Stacey D. Wetmore: Department of Chemistry and Biochemistry, University of Lethbridge, Lethbridge, AB, Canada
Stacey D. Wetmore: Southern Alberta Genome Sciences Centre (SAGSC), University of Lethbridge, Lethbridge, AB, Canada
Stacey D. Wetmore: Alberta RNA Research and Training Institute (ARRTI), University of Lethbridge, Lethbridge, AB, Canada
Stacey D. Wetmore: Canadian Centre of Research in Advanced Fluorine Technologies (C-CRAFT), University of Lethbridge, Lethbridge, AB, Canada
Nehal Thakor: Department of Chemistry and Biochemistry, University of Lethbridge, Lethbridge, AB, Canada
Nehal Thakor: Southern Alberta Genome Sciences Centre (SAGSC), University of Lethbridge, Lethbridge, AB, Canada
Nehal Thakor: Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada
Nehal Thakor: Department of Neuroscience, Canadian Centre for Behavioral Neuroscience (CCBN), University of Lethbridge, Lethbridge, AB, Canada
Nehal Thakor: Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada

DOI: https://doi.org/10.3389/fgene.2021.737433
Journal volume & issue: Vol. 12

Abstract

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Translational control (TC) is one the crucial steps that dictate gene expression and alter the outcome of physiological process like programmed cell death, metabolism, and proliferation in a eukaryotic cell. TC occurs mainly at the translation initiation stage. The initiation factor eIF5B tightly regulates global translation initiation and facilitates the expression of a subset of proteins involved in proliferation, inhibition of apoptosis, and immunosuppression under stress conditions. eIF5B enhances the expression of these survival proteins to allow cancer cells to metastasize and resist chemotherapy. Using eIF5B as a biomarker or drug target could help with diagnosis and improved prognosis, respectively. To achieve these goals, it is crucial to understand the role of eIF5B in translational regulation. This review recapitulates eIF5B’s regulatory roles in the translation initiation of viral mRNA as well as the cellular mRNAs in cancer and stressed eukaryotic cells.

Published in Frontiers in Genetics

ISSN: 1664-8021 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Genetics
Website: http://journal.frontiersin.org/journal/genetics

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