Journal of Biological Research (Sep 2020)

Antibacterial and anti-inflammatory effects of lime (citrus aurantifolia) peel extract in mice balb/c induced salmonella typhi

  • Vivien Novarina Kasim,
  • Mochammad Hatta,
  • Rosdiana Natzir,
  • Veni Hadju,
  • Yusminah Hala,
  • Budu Budu,
  • Gemini Alam,
  • Suryani As'ad,
  • Ami Febriza,
  • Hasta Handayani Idrus



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Lime (Citrus aurantifolia) is a traditional plant that is widely used as antibacterial. This study to prove the effect of lime peel extract (LPE) on the growth of bacterial colonization of S. Typhi medited by activity of IL-6. True experimental pre-post test design, mice were divided into; LPE 510 mg/kgbw, LPE 750 mg/kgbw, positive and negative control. The examination was carried out 3 times, the 5th day before the intervention, the 10th day after the intervention and the 30th day after maintenance. Intervention LPE for 5 days can decreased the number of S. Typhi colonies, even maintenance for 20 days after the intervention showed no bacterial growth . IL-6 pro-inflammatory cytokine activity increased on examination day 5 after S.Typhi injection and decreased after intervention on day 10, significantly different between pre and post at all groups except negative controls (p=0.15). The speed of decrease in IL-6 levels was greatest at the LPE 750 mg/kgbw (velocity=-5.64%). LPE decreased serum levels of IL-6 and inhibit the growth of S. Typhi colony in mice Balb/c. LPE have potential as antibacterial and anti-inflammatory.