Drug Design, Development and Therapy (Mar 2020)
Effects of Cisatracurium, Rocuronium, and Mivacurium on Intraocular Pressure During Induction of General Anesthesia in Ophthalmic Surgery
Abstract
Shuangshuang Li, Xiao Hu, Fang Tan,* Wenxian Li* Department of Anesthesiology, Eye & ENT Hospital of Fudan University, Shanghai 200031, People’s Republic of China *These authors contributed equally to this workCorrespondence: Wenxian LiDepartment of Anesthesiology, Eye & ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai 200031, People’s Republic of ChinaTel +86 13917426838Email [email protected] TanDepartment of Anesthesiology, Eye & ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai 200031, People’s Republic of ChinaTel +86 13611716000Email [email protected]: Maintaining intraocular pressure (IOP) is important in preventing ocular complications in patients undergoing ophthalmic surgery for general anesthesia. The effects of non-depolarizing neuromuscular blockers on IOP remain unclear. The present study compared the effects of cisatracurium, rocuronium, and mivacurium on IOP during induction of general anesthesia in vitreous retinal surgery.Materials and Methods: In this prospective randomized double-blinded study, 133 patients undergoing vitreous retinal surgery were randomized into one of the three groups: Group cisatracurium (n=45), Group rocuronium (n=44), or Group mivacurium (n=44). Each drug (cisatracurium 0.1 mg kg− 1 in Group cisatracurium, rocuronium 0.6 mg kg− 1 in Group rocuronium, and mivacurium 0.2 mg kg− 1 in Group mivacurium) was administered during induction of anesthesia. IOP and hemodynamic parameters were measured at 1 min before anesthesia induction (T0). Bispectral index (BIS) was maintained between 45 and 55 after propofol administration (T1). Train-of-four stimulation (TOF) was below 0 after muscle relaxant administration (T2) and after laryngeal mask implantation (T3).Results: Both ipsi-operative and control-operative IOP at T1, T2, and T3 significantly decreased from the baseline values (T0) in all three groups (P< 0.05). The IOP changes between T1 and T2 among three groups were similar (P> 0.05). The values of systolic blood pressure (SBP) and diastolic blood pressure (DBP) at T1 and T2 significantly decreased in all three groups compared to T0 (P< 0.05).Conclusion: Bilateral IOP significantly decreased from the baseline values in all three groups during the induction phase. Cisatracurium, rocuronium, and mivacurium did not induce significant changes in bilateral IOP.Keywords: intraocular pressure, cisatracurium, rocuronium, mivacurium, general anesthesia, ophthalmic surgery
