Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression

Leonidas S. Lundell; Evelyn B. Parr; Brooke L. Devlin; Lars R. Ingerslev; Ali Altıntaş; Shogo Sato; Paolo Sassone-Corsi; Romain Barrès; Juleen R. Zierath; John A. Hawley

doi:10.1038/s41467-020-18412-w

Nature Communications (Sep 2020)

Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression

Leonidas S. Lundell,
Evelyn B. Parr,
Brooke L. Devlin,
Lars R. Ingerslev,
Ali Altıntaş,
Shogo Sato,
Paolo Sassone-Corsi,
Romain Barrès,
Juleen R. Zierath,
John A. Hawley

Affiliations

Leonidas S. Lundell: Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
Evelyn B. Parr: Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University
Brooke L. Devlin: Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University
Lars R. Ingerslev: Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
Ali Altıntaş: Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
Shogo Sato: Center for Epigenetics and Metabolism, INSERM U1233, Department of Biological Chemistry, School of Medicine, University of California, Irvine
Paolo Sassone-Corsi: Center for Epigenetics and Metabolism, INSERM U1233, Department of Biological Chemistry, School of Medicine, University of California, Irvine
Romain Barrès: Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
Juleen R. Zierath: Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
John A. Hawley: Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University

DOI: https://doi.org/10.1038/s41467-020-18412-w
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

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Time restricted feeding has several health benefits. Here the authors perform a randomised cross-over study with 11 men with overweight/obesity to investigate how time restricted feeding affects skeletal muscle and serum, and report that it does not affect the core circadian machinery, but modifies periodicity in amino acid related metabolites and transporters.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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